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Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation

Constitutive JAK-STAT signaling drives the proliferation of most myeloproliferative neoplasms (MPN) and a subset of acute myeloid leukemia (AML), but persistence emerges with chronic exposure to JAK inhibitors. MPN and post-MPN AML are dependent on tyrosine phosphorylation of STATs, but the role of...

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Principais autores: Ioana I. Nitulescu, Sara C. Meyer, Qiang Jeremy Wen, John D. Crispino, Madeleine E. Lemieux, Ross L. Levine, Henry E. Pelish, Matthew D. Shair
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-12-01
coleção:EBioMedicine
Assuntos:
STAT1
MPN
CDK8
Kinase inhibitor
Leukemia
Super-enhancer
Cortistatin A
Ruxolitinib
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2352396417304565
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