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Integrin αvβ3-dependent pathogenic effect and therapeutic effects of DL-N2 combined with EGFR inhibitors in pancreatic adenocarcinoma

Abstract Background Pancreatic adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by aggressive progression, pronounced stromal desmoplasia, and a limited response to targeted therapies. Although epidermal growth factor receptor (EGFR) inhibitors have shown promise in p...

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Principais autores: Zi-Lin Li, Sachin Kumar, San-Nan Yang, Tung-Cheng Chang, Lin-Yi Huang, Ching-Chung Ko, Yung-Ning Yang, Chih-Jung Yao, Dana R. Crawford, Fabio Gionfra, Dahlak Daniel Solomon, Yung-Kuo Lee, Do Thi Minh Xuan, Hui-Ru Lin, Chih-Yang Wang, Amruta Aher, Nandana Bayu Abhista, Ya-Jung Shih, Sheng-Yang Lee, Haw-Ming Huang, Hung-Yun Lin, Kuan Wang, Jaqueline Whang-Peng
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-02-01
coleção:Journal of Translational Medicine
Acesso em linha:https://doi.org/10.1186/s12967-026-07865-0
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