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Proinflammatory and Th2 cytokines regulate the high affinity IgE receptor (FcepsilonRI) and IgE-dependant activation of human airway smooth muscle cells.

BACKGROUND:The high affinity IgE receptor (FcepsilonRI) is a crucial structure for IgE-mediated allergic reactions. We have previously demonstrated that human airway smooth muscle (ASM) cells express the tetrameric (alphabetagamma2) FcepsilonRI, and its activation leads to marked transient increases...

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Principais autores: Naresh Singh Redhu, Ali Saleh, Lianyu Shan, William T Gerthoffer, Sam K Kung, Andrew J Halayko, Bouchaib Lamkhioued, Abdelilah S Gounni
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2009-07-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC2701636?pdf=render
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