Pharmacokinetic–pharmacodynamic cutoff values for benzylpenicillin in horses to support the establishment of clinical breakpoints for benzylpenicillin antimicrobial susceptibility testing in horses

IntroductionThe aim of this international project was to establish a species-specific Clinical Breakpoint for interpretation of Antimicrobial Susceptibility Testing of benzylpenicillin (BP) in horses.MethodsA population pharmacokinetic model of BP disposition was developed to compute PK/PD cutoff va...

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Hauptverfasser:	Elodie A. Lallemand, Alain Bousquet-Mélou, Laura Chapuis, Jennifer Davis, Aude A. Ferran, Butch Kukanich, Taisuke Kuroda, Marlène Z. Lacroix, Yohei Minamijima, Lena Olsén, Ludovic Pelligand, Felipe Ramon Portugal, Béatrice B. Roques, Elizabeth M. Santschi, Katherine E. Wilson, Pierre-Louis Toutain
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-10-01
Schriftenreihe:	Frontiers in Microbiology
Schlagworte:	benzylpenicillin horse antimicrobial susceptibility testing PK/PD cutoff population pharmacokinetics Monte Carlo simulations
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fmicb.2023.1282949/full
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