Plasma Aβ42/Aβ40 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer’s disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort

Background: The accurate identification of individuals at risk of Alzheimer’s disease (AD) through blood-based biomarkers remains challenging. Objectives: To evaluate the association between plasma amyloid-beta (Aβ)42/Aβ40 ratio and longitudinal amyloid deposition, clinical progression, brain atroph...

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Autors principals:	Noelia Fandos, María Pascual-Lucas, Leticia Sarasa, Jose Terencio, Mª Eugenia Sáez, Juan Pablo Tartari, Ángela Sanabria, Oscar Sotolongo-Grau, Amanda Cano, Lluís Tárraga, Miren Jone Gurruchaga, Agustín Ruíz, Xavier Montalban, Mercè Boada, Montserrat Alegret, Marta Marquié, José Antonio Allué, N. Aguilera, E. Alarcón-Martín, M. Alegret, J.A. Alllué, P. Bayón-Bujan, M. Berthier, J. Blázquez-Folch, M. Boada, M. Buendia, S. Bullich, F. Campos, B. Calm-Salvans, A. Cano, F. Casales, P. Cañabate, L. Cañada, C. Cuevas, I. de Rojas, S. Diego, G. Domingues-Kolinger, J.M. Escudero, A. Espinosa, N. Fandos, M.V. Fernández, A. Gailhajenet, P. García-González, J. Giménez, M. Gómez-Chiari, M. Guitart, M.J. Gurruchaga, P.C. Gutiérrez, I. Hernández, M. Ibarria, A. Lafuente, F. Lomeña, M. Marquié, E. Martín, C. Martínez, M. Martinez, A. Miguel, M. Moreno, A. Morera, L. Montrreal, N. Muñoz, A. Muñoz-Morales, A. Niñerola, A.B. Nogales, L. Núñez, C. Olivé, A. Orellana, G. Ortega, A. Páez, A. Pancho, E. Pelejà, E. Pérez-Martínez, A. Pérez-Cordon, V. Pérez-Grijalba, M. Pascual-Lucas, A. Perissinotti, S. Preckler, R. Puerta, M.I. Ramis, J.N. Rodríguez, N. Roé-Vellvé, J. Romero, M. Rosende-Roca, A. Ruiz, A. Sanabria, P. Sanz-Cartagena, L. Sarasa, S. Seguer, A. Solivar, O. Sotolongo-Grau, A. Stephens, J.P. Tartari, L. Tárraga, M.A. Tejero, J. Terencio, M. Torres, A. Valenzuela, S. Valero, L. Vargas, A. Vivas
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-03-01
Col·lecció:	The Journal of Prevention of Alzheimer's Disease
Matèries:	Alzheimer’s disease Aβ42/Aβ40 Blood biomarkers Mass spectrometry Subjective cognitive decline
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2274580725004066
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