Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

Mammalian circadian rhythms are generated by a transcription-based feedback loop in which CLOCK:BMAL1 drives transcription of its repressors (PER1/2, CRY1/2), which ultimately interact with CLOCK:BMAL1 to close the feedback loop with ~24 hr periodicity. Here we pinpoint a key difference between CRY1...

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Detalhes bibliográficos

Principais autores:	Jennifer L Fribourgh, Ashutosh Srivastava, Colby R Sandate, Alicia K Michael, Peter L Hsu, Christin Rakers, Leslee T Nguyen, Megan R Torgrimson, Gian Carlo G Parico, Sarvind Tripathi, Ning Zheng, Gabriel C Lander, Tsuyoshi Hirota, Florence Tama, Carrie L Partch
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2020-02-01
coleção:	eLife
Assuntos:	circadian rhythms x-ray crystallography cryo-electron microscopy molecular dynamics
Acesso em linha:	https://elifesciences.org/articles/55275
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