Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features

Abstract Background Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant research on tumour evolution in prostate cancer metastasis, the emergence and evolution of cancer clones at this early stage of expans...

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Detalles Bibliográficos

Principais autores:	Srinivasa Rao, Clare Verrill, Lucia Cerundolo, Nasullah Khalid Alham, Zeynep Kaya, Miriam O’Hanlon, Alicia Hayes, Adam Lambert, Martha James, Iain D. C. Tullis, Jane Niederer, Shelagh Lovell, Altan Omer, Francisco Lopez, Tom Leslie, Francesca Buffa, Richard J. Bryant, Alastair D. Lamb, Boris Vojnovic, David C. Wedge, Ian G. Mills, Dan J. Woodcock, Ian Tomlinson, Freddie C. Hamdy
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-02-01
Series:	Genome Medicine
Assuntos:	Prostate cancer Cancer evolution Histopathology Prostate cancer metastasis Intra-tumour heterogeneity Spatial genomic analysis
Acceso en liña:	https://doi.org/10.1186/s13073-024-01302-x
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