Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein

Protein-nucleic acid phase separation has been implicated in many diseases such as viral infections, neurodegeneration, and cancer. There is great interest in identifying condensate modulators (CMODs), which are small molecules that alter the dynamics and functions of phase-separated condensates, as...

Disgrifiad llawn

Manylion Llyfryddiaeth

Prif Awduron:	Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young, Kierra S. Hardy, Samuel Lim, Phillip J. Elms, David T. McSwiggen, Timothy J. Mitchison, Pamela A. Silver
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2025-03-01
Cyfres:	SLAS Discovery
Pynciau:	Biomolecular condensates High content screening single molecule tracking Split luciferase NanoBRET Dynamics
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S2472555225000139
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!