CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients

Pancreatic ductal adenocarcinoma (PDAC) is currently the most deadly cancer. Although characterized by 5–20% of neoplastic cells in the highly fibrotic stroma, immunotherapy is not a valid option in PDAC treatment. As CXCR4-CXCL12 regulates tumor invasion and T-cell access and PD-1/PD-L1 controls im...

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Bibliographic Details

Main Authors:	Crescenzo D’Alterio, Alessandro Giardino, Giosuè Scognamiglio, Giovanni Butturini, Luigi Portella, Giuseppe Guardascione, Isabella Frigerio, Marco Montella, Stefano Gobbo, Guido Martignoni, Vincenzo Napolitano, Ferdinando De Vita, Fabiana Tatangelo, Renato Franco, Stefania Scala
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2022-10-01
Series:	Cells
Subjects:	pancreatic adenocarcinoma (PDAC) CXCR4-CXCL12-CXCR7 axis immune checkpoint PD-1/PD-L1 chemokine receptor tumor microenvironment (TME) outcome
Online Access:	https://www.mdpi.com/2073-4409/11/21/3340
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