Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches

Abstract Clozapine is a potent serotonin receptor antagonist and commonly used for the treatment of Schizophrenia. The study aimed to develop and optimize the transdermal matrix patch of clozapine. A 3-level, 3-factor Central Composite Design was applied to examine and validate the impact of various...

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Главные авторы:	Abdul Qadir, Syed Umer Jan, Muhammad Harris Shoaib, Muhammad Sikandar, Rabia Ismail Yousuf, Fatima Ramzan Ali, Fahad Siddiqui, Abdul Jabbar Magsi, Ghulam Mustafa, Muhammad Talha Saleem, Shafi Mohammad, Mohammad Younis, Muhammad Arsalan
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2025-01-01
Серии:	Scientific Reports
Предметы:	Central composite design PBPK Transdermal drug delivery Permeation enhancers, in silico In vitro In vivo
Online-ссылка:	https://doi.org/10.1038/s41598-024-81918-6
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