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Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance.

SIRT1 is a NAD+-dependent deacetylase thought to regulate cellular metabolic pathways in response to alterations in nutrient flux. In the current study we investigated whether acute changes in SIRT1 expression affect markers of muscle mitochondrial content and also determined whether SIRT1 influence...

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主要な著者: Amanda E Brandon, Jennifer Tid-Ang, Lauren E Wright, Ella Stuart, Eurwin Suryana, Nicholas Bentley, Nigel Turner, Gregory J Cooney, Neil B Ruderman, Edward W Kraegen
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science (PLoS) 2015-01-01
シリーズ:PLoS ONE
オンライン・アクセス:http://europepmc.org/articles/PMC4370576?pdf=render
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