Ubiquitin-binding site 1 of pathogenic ataxin-3 regulates its toxicity in Drosophila models of Spinocerebellar Ataxia Type 3

Spinocerebellar Ataxia Type 3 (SCA3) is a member of the family of polyglutamine (polyQ) diseases that are caused by anomalous CAG triplet repeat expansions in several genes. SCA3 results from abnormal polyQ expansion in the deubiquitinase (DUB), ataxin-3 (Atxn3). To understand the role of the differ...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Matthew V. Prifti, Kozeta Libohova, Autumn L. Harris, Wei-Ling Tsou, Sokol V. Todi
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2023-01-01
Цуврал:	Frontiers in Neuroscience
Нөхцлүүд:	ataxia CAG triplet repeat Drosophila misfolding and aggregation neurodegeneration polyglutamine (polyQ)
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fnins.2022.1112688/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!