A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination

Abstract Age-related decline in mobility and cognition are associated with cellular senescence and NAD + depletion in dogs and people. A combination of a novel NAD + precursor and senolytic, LY-D6/2, was examined in this randomized controlled trial. Seventy dogs with mild to moderate cognitive impai...

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Autores principales:	Katherine E. Simon, Katharine Russell, Alejandra Mondino, Chin-Chieh Yang, Beth C. Case, Zachary Anderson, Christine Whitley, Emily Griffith, Margaret E. Gruen, Natasha J. Olby
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2024-05-01
Colección:	Scientific Reports
Materias:	Aging Senolytic NAD+ Canine cognitive dysfunction syndrome Cognitive impairment Longevity
Acceso en línea:	https://doi.org/10.1038/s41598-024-63031-w
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