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First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease

Recently, the direct thrombin (thr) inhibitor dabigatran has proven to be beneficial in animal models of Alzheimer’s disease (AD). Aiming at discovering novel multimodal agents addressing thr and AD-related targets, a selection of previously and newly synthesized potent thr and factor Xa (fXa) inhib...

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Principais autores: Rosa Purgatorio, Nicola Gambacorta, Modesto de Candia, Marco Catto, Mariagrazia Rullo, Leonardo Pisani, Orazio Nicolotti, Cosimo D. Altomare
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2021-08-01
Series:Molecules
Assuntos:
acetylcholinesterase
butyrylcholinesterase
Alzheimer’s disease
antithrombotic agents
isonipecotamides
Acceso en liña:https://www.mdpi.com/1420-3049/26/17/5208
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