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DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific

The death-associated protein kinase 1 (DAPK1) is a potent mediator of neuronal cell death. Here, we find that DAPK1 also functions in synaptic plasticity by regulating the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII). CaMKII and T286 autophosphorylation are required for both long-term...

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Autori principali: Dayton J. Goodell, Vincent Zaegel, Steven J. Coultrap, Johannes W. Hell, K. Ulrich Bayer
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017-06-01
Serie:Cell Reports
Soggetti:
DAPK1
CaMKII
calcineurin
GluN2B
LTP
LTD
hippocampus
synapse
dendritic spine
death-associated protein kinase
Accesso online:http://www.sciencedirect.com/science/article/pii/S2211124717307258
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