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Synthesis of 4′-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents

Over the past decades, both 4′-modified nucleoside and carbocyclic nucleoside analogs have been under the spotlight as several compounds from either family showed anti-HIV, HCV, RSV or SARS-CoV-2 activity. Herein, we designed compounds combining these two features and report the synthesis of a serie...

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Principais autores: Nicolas G. Biteau, Sarah A. Amichai, Niloufar Azadi, Ramyani De, Jessica Downs-Bowen, Julia C. Lecher, Tamara MacBrayer, Raymond F. Schinazi, Franck Amblard
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2023-02-01
סדרה:Viruses
נושאים:
antivirals
prodrugs
carbocyclic nucleosides
viral polymerase
SARS-CoV-2
influenza virus
גישה מקוונת:https://www.mdpi.com/1999-4915/15/2/544
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