Evaluation and Mitigation of Time‐Dependent Confounding Effects in Conventional Exposure‐Response Analyses for Oncology Drugs

ABSTRACT Conventional exposure–response (E–R) analyses, such as logistic regression and time‐to‐event analysis using summary exposure metrics, are often conducted in oncology using data from the pivotal trial(s) with a single dose level to support dosing decisions. However, these E–R analyses, affec...

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Autores principales:	Xuefen Yin, Ye Xiong, Youwei Bi, Xin Wei, Hong Zhao, Elimika Pfuma Fletcher, Rajanikanth Madabushi, Amal Ayyoub, Hao Zhu, Stephan Schmidt, Jiang Liu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2025-12-01
Colección:	CPT: Pharmacometrics & Systems Pharmacology
Materias:	bias control dose modification exposure–response oncology dosing PK accumulation time‐dependent confounding factors
Acceso en línea:	https://doi.org/10.1002/psp4.70119
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