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Study on the CHJ01 antitumor activity and mechanism via targeting sphingosine kinase 1 in A549 cells

The SphK1 inhibitor development is of great importance for the treatment of non-small cell lung cancer (NSCLC). In this study, CHJ01 which has been previously shown anti-tumor effects was introduced to investigate the detailed antitumor mechanism both in vitro and in vivo. CHJ01 inhibited the A549 ​...

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Wedi'i Gadw mewn:
Prif Awduron: Caiyu Liu, Shengmei Gao, Bo Liu, Feipeng Zhang, Yanling Mu, Fuwen Wang, Yan Li
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2025-12-01
Cyfres:Pharmaceutical Science Advances
Pynciau:
CHJ01
Sphingosine kinase 1
A549
TRAF2/NF-κB signaling pathway
Apoptosis
Non-small cell lung cancer
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S2773216925000157
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