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The SMARCA4 subunit of the SWI/SNF complex prevents genome instability at G quadruplexes

Abstract Background G-quadruplex (G4) structures are secondary structures that can form in guanine-rich single stranded DNA sequences. These play important roles in biological processes such as regulation of gene expression but can also pose challenges to DNA replication and lead to genome instabili...

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Autori principali: Alison Harrod, Hugang Feng, Nagham Ghaddar, Federica Schiavoni, Karen A. Lane, Lillian Wu, Pedro Zuazua-Villar, Zuzanna Kozik, Felix M. Dobbs, Patrick van Eijk, Gene Ching Chiek Koh, Navita Somaiah, Jyoti Choudhary, Serena Nik-Zainal, Simon H. Reed, Jessica A. Downs
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2026-04-01
Serie:Genome Biology
Soggetti:
SMARCA4
BRG1
SWI/SNF
Genome instability
G quadruplex
Pyridostatin
Accesso online:https://doi.org/10.1186/s13059-026-04080-4
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