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Inflammation reprograms fibro-adipogenic progenitors to sustain immunopathogenic niches in myositis

Abstract Idiopathic inflammatory myopathies (IIMs) are autoimmune disorders defined by persistent muscle inflammation, fibrosis, and frequent resistance to current therapies. However, the mechanisms perpetuating disease activity despite immunosuppressive treatment remain elusive. Here, we describe a...

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Principais autores: Christopher Nelke, Julian Sanchez-Dal Cin, Charles-Antoine Dallevet, Jin-Soo Park, Jacqueline C. Kinold, Christina B. Schroeter, Felix Kleefeld, Anne-Katrin Güttsches, Paula Quint, Sara Walli, Derya Cengiz, Vera Dobelmann, Corinna Preusse, Alexander Mensch, Anne Schänzer, Markus Leo, Tim Hagenacker, Benedikt Schoser, Jörg H. W. Distler, Akiyoshi Uezumi, Werner Stenzel, Sven G. Meuth, Olivier Benveniste, Yves Allenbach, Tobias Ruck
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2026-06-01
coleção:Cell Death and Disease
Acesso em linha:https://doi.org/10.1038/s41419-026-08966-w
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