Assessment of leachables in hospital pharmacy compounded topotecan conditioned in common off-label syringes for intravitreal use

Abstract Compounding drug products is a vital hospital pharmacy feature that requires safe and compatible primary packaging, particularly for prefilled syringes (PFSs). The off-label use of plastic syringes in batch compounding for intravitreal administration has raised concerns over leachables and...

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Detalhes bibliográficos

Principais autores:	William Bello, Camille Hosotte, Camille Stampfli, Antoine Pierrot, Francis L. Munier, Markoulina Berger-Gryllaki, Laurent Carrez, Julian Pezzatti, Farshid Sadeghipour
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-11-01
Colecção:	Scientific Reports
Assuntos:	Hospital pharmacy compounding Prefilled syringes Topotecan Intravitreal administration UHPLC-HRMS Leachables
Acesso em linha:	https://doi.org/10.1038/s41598-025-24557-9
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