Polyglutamine-expanded ATXN7 alters a specific epigenetic signature underlying photoreceptor identity gene expression in SCA7 mouse retinopathy

Abstract Background Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder that primarily affects the cerebellum and retina. SCA7 is caused by a polyglutamine expansion in the ATXN7 protein, a subunit of the transcriptional coactivator SAGA that acetylates histone H3 to deposit narrow...

Disgrifiad llawn

Manylion Llyfryddiaeth

Prif Awduron:	Anna Niewiadomska-Cimicka, Antoine Hache, Stéphanie Le Gras, Céline Keime, Tao Ye, Aurelie Eisenmann, Imen Harichane, Michel J. Roux, Nadia Messaddeq, Emmanuelle Clérin, Thierry Léveillard, Yvon Trottier
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2022-12-01
Cyfres:	Journal of Biomedical Science
Pynciau:	Spinocerebellar ataxia type 7 Photoreceptor dystrophy SAGA Epigenomics Transcriptomics Neuronal identity
Mynediad Ar-lein:	https://doi.org/10.1186/s12929-022-00892-1
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!