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Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy

Summary: To solve the clinical transformation dilemma of lamin A/C (LMNA)-mutated dilated cardiomyopathy (LMD), we developed an LMNA-mutated primate model based on the similarity between the phenotype of primates and humans. We screened out patients with LMD and compared the clinical data of LMD wit...

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Principais autores: Xiang Luo, PhD, Hao Jia, MD, PhD, Fang Wang, PhD, Han Mo, MS, Yu Kang, PhD, Ningning Zhang, MS, Lu Zhao, PhD, Lizhu Xu, MS, Zhengsheng Yang, BS, Qiaoyan Yang, PhD, Yuan Chang, MD, PhD, Shulin Li, PhD, Ning Bian, MS, Xiumeng Hua, MD, PhD, Hao Cui, PhD, Yu Cao, MD, Chu Chu, PhD, Yuqiang Zeng, PhD, Xinglong Chen, BS, Zhigang Chen, BS, Weizhi Ji, PhD, Chengzu Long, PhD, Jiangping Song, MD, PhD, Yuyu Niu, PhD
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-03-01
coleção:JACC: Basic to Translational Science
Assuntos:
CRISPR-mediated adenine base editing
dilated cardiomyopathy
lamin A/ C
primate model
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2452302X23005156
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