A Convenient Synthesis of (16<i>S</i>,20<i>S</i>)-3β-Hydroxy-5α-pregnane-20,16-carbolactam and Its <i>N</i>-alkyl Derivatives

A concise synthesis of (16<i>S</i>,20<i>S</i>)-3β-hydroxy-5α-pregnane-20,16-carbolactam from tigogenin via the corresponding lactone is described. The most efficient synthetic route consisted of the lactone ring-opening with aminoalane reagent followed by PDC or Dess-Martin oxidation. The oxo-amide...

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Главные авторы:	Agnieszka Wojtkielewicz, Damian Pawelski, Przemysław Bazydło, Aneta Baj, Stanisław Witkowski, Jacek W. Morzycki
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2020-05-01
Серии:	Molecules
Предметы:	lactams reductive amination spirostane degradation steroids
Online-ссылка:	https://www.mdpi.com/1420-3049/25/10/2377
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