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Celastrol increases anoikis sensitivity to suppress triple-negative breast cancer via EGFR pathway and p-EMT state regulation

Faced with the highly malignant threat of metastatic triple-negative breast cancer (TNBC), the effect of traditional chemical agents is limited, and new anti-metastasis drug remains to be explored. Celastrol (Cel) is a bioactive compound derived from Tripterygium wilfordii with significant anti-neop...

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Principais autores: Jue Yang, Xiangpeng Wang, Xiuyun Bai, Rongjun Deng, Wanting Ye, Qiqiong Liu, Ying Xing, Yuxing Yao, Aiping Lyu, Cheng Lu, Yuanyan Liu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-03-01
coleção:Frontiers in Pharmacology
Assuntos:
anoikis
celastrol
circulating tumor cells
triple-negative breast cancer
tumor metastasis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2026.1747871/full
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