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Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice

The progression of Alzheimer’s disease (AD) correlates with the propagation of hyperphosphorylated tau (pTau) from the entorhinal cortex to the hippocampus and neocortex. Neutral sphingomyelinase2 (nSMase2) is critical in the biosynthesis of extracellular vesicles (EVs), which play a role in pTau pr...

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Autori principali: Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D. J. Huizar, Silvia Picciolini, Ajit G. Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M. Kannan, Marzia Bedoni, Rana Rais, Barbara S. Slusher
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2023-09-01
Serie:Pharmaceutics
Soggetti:
Alzheimer’s disease
DPTIP
hydroxyl PAMAM dendrimer
D-DPTIP
extracellular vesicles
neutral sphingomyelinase 2
Accesso online:https://www.mdpi.com/1999-4923/15/9/2364
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