SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and Microscale Accelerated Molecular Dynamics

The Receptor Binding Domain (RBD) of SARS-CoV-2 virus harbors a sequence of Arg-Gly-Asp tripeptide named RGD motif, which has also been identified in extracellular matrix proteins that bind integrins as well as other disintegrins and viruses. Accordingly, integrins have been proposed as host recepto...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Houcemeddine Othman, Haifa Ben Messaoud, Oussema Khamessi, Hazem Ben-Mabrouk, Kais Ghedira, Avani Bharuthram, Florette Treurnicht, Ikechukwu Achilonu, Yasien Sayed, Najet Srairi-Abid
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2022-02-01
Schriftenreihe:	Frontiers in Molecular Biosciences
Schlagworte:	SARS-CoV-2 COVID-19 integrin RBD molecular dynamcis
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.834857/full
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