Multitargeted nanoparticles inhibit cancer invasion by disrupting cancer-associated fibroblast-tumor cell crosstalk and modulating collagen pattern and EMT

Abstract Background Cancer-associated fibroblasts (CAFs), a major component of tumor stroma, play an important role in tumor progression and metastasis via paracrine signaling, extracellular matrix (ECM) remodelling, and the secretion of growth factors, cytokines, and chemokines promoting tumor grow...

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Ngā kaituhi matua:	Liting Wang, Pei Zhi, Ibrahim Alradwan, Chunsheng He, Azhar Z. Abbasi, Han Gao, Andrew M. Rauth, David W. Cescon, Jeffrey T. Henderson, Xiao Yu Wu
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2026-05-01
Rangatū:	Journal of Nanobiotechnology
Ngā marau:	Cancer-associated fibroblast (CAF) CAF-cancer interactions Tumor microenvironment Triple negative breast cancer Multitargeted nanoparticles Tumor-associated collagen signatures
Urunga tuihono:	https://doi.org/10.1186/s12951-026-04526-8
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!