The plasmacytoid dendritic cell paradox in cancer: impaired type I interferon responses in a nucleic acid–rich tumor microenvironment

Plasmacytoid dendritic cells (pDCs) are specialized immune cells best known for their ability to produce large amounts of type I interferons (IFN-I) upon nucleic acid sensing through endosomal Toll-like receptors (TLR)-7/8 and 9. In tumors, the accumulation of nucleic acids (NAs) deriving from exten...

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Hauptverfasser:	Aliki Vasilakou, Séverine Loizon, Maxime Dubois, Paôline Laurent, Vanja Sisirak, Dorothée Duluc
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-07-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	cancer microenvironment nucleic acid plasmacytoid dendritic cells type I IFN
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1847012/full
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