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Hotspots of De Novo Point Mutations in Induced Pluripotent Stem Cells

Summary: Induced pluripotent stem cells (iPSCs) are generated by direct reprogramming of somatic cells and hold great promise for novel therapies. However, several studies have reported genetic variations in iPSC genomes. Here, we investigated point mutations identified by whole-genome sequencing in...

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Bibliografische gegevens
Hoofdauteurs: Masahito Yoshihara, Ryoko Araki, Yasuji Kasama, Misato Sunayama, Masumi Abe, Kohji Nishida, Hideya Kawaji, Yoshihide Hayashizaki, Yasuhiro Murakawa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2017-10-01
Reeks:Cell Reports
Online toegang:http://www.sciencedirect.com/science/article/pii/S2211124717313505
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