Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.

As primary p53 antagonists, Mdm2 and the closely related Mdm4 are relevant cancer therapeutic targets. We have previously described a series of cell-permeable stapled peptides that bind to Mdm2 with high affinity, resulting in activation of the p53 tumour suppressor. Within this series, highest affi...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Sharon Min Qi Chee, Jantana Wongsantichon, Jiawei Siau, Dawn Thean, Fernando Ferrer, Robert C Robinson, David P Lane, Christopher J Brown, Farid J Ghadessy
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Public Library of Science (PLoS) 2017-01-01
Sarja:	PLoS ONE
Linkit:	http://europepmc.org/articles/PMC5724825?pdf=render
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