Elevated SUN1 promotes migratory cell polarity defects through mechanically coupling microtubules to the nuclear lamina
Abstract In migratory fibroblasts, front-rear polarity is defined by the centrosome positioned anterior to a rearward nucleus. To achieve this polarity, actin cables couple to nuclear membrane proteins nesprin-2G and SUN2 and drive the nucleus backward. Aging disrupts this polarity by increasing SUN...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2025-12-01
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| Serie: | Communications Biology |
| Accesso online: | https://doi.org/10.1038/s42003-025-09229-8 |
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