Regulation of AMPK activation by extracellular matrix stiffness in pancreatic cancer

The adenosine monophosphate (AMP)-activated protein kinase (AMPK) sits at a central node in the regulation of energy metabolism and tumor progression. AMPK is best known to sense high cellular ADP or AMP levels, which indicate the depletion of energy stores. Previous studies have shown that the low...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Xin Xu, Yuan Fang, Somaira Nowsheen, Ye-Xiong Li, Zhenkun Lou, Min Deng
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	KeAi Communications Co., Ltd. 2024-05-01
Schriftenreihe:	Genes and Diseases
Schlagworte:	AMPK activity Cellular metabolic switch ECM stiffness Hippo kinase signaling Pancreatic ductal adenocarcinoma
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2352304223003057
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