Oxidation of 2-Hydroxynevirapine, a Phenolic Metabolite of the Anti-HIV Drug Nevirapine: Evidence for an Unusual Pyridine Ring Contraction

Nevirapine (NVP) is an anti-HIV drug associated with severe hepatotoxicity and skin rashes, which raises concerns about its chronic administration. There is increasing evidence that metabolic activation to reactive electrophiles capable of reacting with bionucleophiles is likely to be involved in th...

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Bibliografiske detaljer

Principais autores:	Frederick A. Beland, João L. Ferreira da Silva, Pedro P. Santos, Shrika G. Harjivan, David A. Novais, Muna Sidarus, Alexandra M. M. Antunes, M. Matilde Marques
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2012-03-01
Serier:	Molecules
Fag:	anti-HIV drug nevirapine oxidation pyridine ring contraction
Online adgang:	http://www.mdpi.com/1420-3049/17/3/2616/
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