Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort

Abstract Background There is a lack of mechanism-driven, clinically relevant biomarkers in chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction, a proposed disease mechanism in COPD, is associated with the release of mitochondrial DNA (mtDNA), but plasma cell-free mtDNA has not be...

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Detalhes bibliográficos

Principais autores:	William Z. Zhang, Katherine L. Hoffman, Kristen T. Schiffer, Clara Oromendia, Michelle C. Rice, Igor Barjaktarevic, Stephen P. Peters, Nirupama Putcha, Russell P. Bowler, J. Michael Wells, David J. Couper, Wassim W. Labaki, Jeffrey L. Curtis, Meilan K. Han, Robert Paine, Prescott G. Woodruff, Gerard J. Criner, Nadia N. Hansel, Ivan Diaz, Karla V. Ballman, Kiichi Nakahira, Mary E. Choi, Fernando J. Martinez, Augustine M. K. Choi, Suzanne M. Cloonan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-04-01
coleção:	Respiratory Research
Assuntos:	COPD Mitochondrial dysfunction mtDNA SPIROMICS
Acesso em linha:	https://doi.org/10.1186/s12931-021-01707-x
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