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In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons

Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies against Aβ capture Aβ and its precursor proteins (i.e., APP and...

Celý popis

Uloženo v:
Hlavní autoři: Alec K. McKendell, Mei C. Q. Houser, Shane P. C. Mitchell, Michael S. Wolfe, Oksana Berezovska, Masato Maesako
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2022-08-01
Edice:Biosensors
Témata:
Alzheimer’s disease
fluorescence resonance energy transfer (FRET)
γ-secretase
glycoconjugates
intracellular amyloid-beta (Aβ)
lysosomes
On-line přístup:https://www.mdpi.com/2079-6374/12/8/663
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