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Cyclodextrins as modulators for separation of charged variants of mAbs by capillary zone electrophoresis

Charge heterogeneity is a critical quality attribute for mAb-based therapeutics. Its characterization involves the identification of charge variant species in the final formulation. Capillary zone electrophoresis (CZE) is a valuable tool to assess charge heterogeneity, but typically offers incomplet...

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Principais autores: Ramesh Kumar, Gayatri Vishwakarma, Anurag S. Rathore
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021-11-01
Series:Journal of Chromatography Open
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Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2772391721000116
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