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The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Identifying women at high risk of breast cancer has important implications for screening. Here, the authors demonstrate that polygenic risk scores improve breast cancer risk prediction in the population, in women with mutations in high-risk genes and in women with close relatives with the disease.

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Detalhes bibliográficos
Principais autores: Nina Mars, Elisabeth Widén, Sini Kerminen, Tuomo Meretoja, Matti Pirinen, Pietro della Briotta Parolo, Priit Palta, FinnGen, Aarno Palotie, Jaakko Kaprio, Heikki Joensuu, Mark Daly, Samuli Ripatti
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2020-12-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-020-19966-5
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