Interruption of Capsular Polysaccharide Biosynthesis Gene wbaZ by Insertion Sequence IS903B Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae

ABSTRACT Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major challenge for clinical management worldwide with limited antimicrobial options. Phages are considered an alternative option. Here, we isolated and identified a phage able to lyse ST11-K64 CRKP, the major type in China. This phage...

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Detalhes bibliográficos

Principais autores:	Xin Yin, Qingqing Fang, Zhiyong Zong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2022-12-01
coleção:	mSphere
Assuntos:	phage therapy Klebsiella pneumoniae K64 capsule polysaccharide phage resistance Klebsiella
Acesso em linha:	https://journals.asm.org/doi/10.1128/msphere.00518-22
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