Leveraging Hot Spots of TEAD–Coregulator Interactions in the Design of Direct Small Molecule Protein-Protein Interaction Disruptors Targeting Hippo Pathway Signaling

The Hippo signaling pathway is a highly conserved pathway that plays important roles in the regulation of cell proliferation and apoptosis. Transcription factors TEAD1-4 and transcriptional coregulators YAP/TAZ are the downstream effectors of the Hippo pathway and can modulate Hippo biology. Dysregu...

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Bibliografiset tiedot

Päätekijät:	Bin Zhao, Ajaybabu V. Pobbati, Brian P. Rubin, Shaun Stauffer
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	MDPI AG 2023-04-01
Sarja:	Pharmaceuticals
Aiheet:	TEAD YAP VGLL protein-protein interaction Hippo pathway transcription
Linkit:	https://www.mdpi.com/1424-8247/16/4/583
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