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Subinhibitory Concentrations of Rifampicin Synergize with Linezolid to Delay Resistance Evolution in Clinical Methicillin-Resistant Staphylococcus Aureus

Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a multidrug-resistant pathogen. Long-term clinical use of linezolid readily induces bacterial resistance in MRSA. This study explored resistance evolution and related mechanisms of MRSA to linezolid under subinhibitory concentrations of ri...

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Principais autores: Chunhua Peng, Lu Lai, Chuanwei Zhang, Menglin Hu, Yalong Qi, Fangrui Liang, Ziyan Chen, Sailan Wang, Xiaohui Huang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-06-01
Serier:Microorganisms
Fag:
drug resistance
in vitro antibacterial activity
linezolid
MRSA
resistance gene
rifampicin
Online adgang:https://www.mdpi.com/2076-2607/14/6/1310
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