ATM knock out alters calcium signalling and augments contraction in skeletal muscle cells differentiated from human urine-derived stem cells

Abstract Ataxia-telangiectasia (A-T) is a rare neurodegenerative disorder caused by the deficiency of the serine/threonine kinase ataxia telangiectasia mutated (ATM) protein, whose loss of function leads to altered cell cycle, apoptosis, oxidative stress balance and DNA repair after damage. The clin...

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Egile Nagusiak:	Giulia Dematteis, Giulia Lecchi, Giulia Boni, Diana Pendin, Carla Distasi, Mariagrazia Grilli, Dmitry Lim, Luigia Grazia Fresu, Maria Talmon
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Publishing Group 2025-04-01
Saila:	Cell Death Discovery
Sarrera elektronikoa:	https://doi.org/10.1038/s41420-025-02485-x
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