Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (ShhNp) at a 4:2 stoichiometric ratio.
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2019-05-01
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| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/s41467-019-10234-9 |
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