Cuttlefish ink nanoparticle hydrogels ameliorate osteoarthritis via concurrent inhibition of macrophage pyroptosis and chondrocyte senescence

Abstract Osteoarthritis (OA) is a debilitating joint disorder characterized by synovial inflammation and cartilage degradation; however, current therapeutic options fail to simultaneously address these dual pathological progressions. Here, we present clinical evidence identifying synovial macrophage...

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Κύριοι συγγραφείς:	Zhou Xu, Yuan Fang, Yuesheng Wang, Haixiang Miao, Tangjie Zhang, Peng Cao, Yi Zhang, Gang Chen
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2026-04-01
Σειρά:	Journal of Nanobiotechnology
Θέματα:	Cuttlefish ink Melanin nanoparticle Metabolic reprogramming Synovium pyroptosis Cartilage senescence
Διαθέσιμο Online:	https://doi.org/10.1186/s12951-026-04396-0
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