C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency

Alpha-1 antitrypsin (AAT) deficiency (AATD) is characterized by increased risk for emphysema, chronic obstructive pulmonary disease (COPD), vasculitis, and wound-healing impairment. Neutrophils play a central role in the pathogenesis of AATD. Dysregulated complement activation in AATD results in inc...

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Detalhes bibliográficos

Principais autores:	Laura T. Fee, Debananda Gogoi, Michael E. O’Brien, Emer McHugh, Michelle Casey, Ciara Gough, Mark Murphy, Ann M. Hopkins, Tomás P. Carroll, Noel G. McElvaney, Emer P. Reeves
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-12-01
coleção:	Biomedicines
Assuntos:	neutrophils alpha-1 antitrypsin alpha-1 antitrypsin deficiency complement component 3d degranulation neutrophil elastase
Acesso em linha:	https://www.mdpi.com/2227-9059/9/12/1925
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