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Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain

Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson’s and Alzheimer’s disease, our understanding of retromer function in the adult brain remains limited, in part because Vps35 and...

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Kaydedildi:
Asıl Yazarlar: Hui Ye, Shamsideen A Ojelade, David Li-Kroeger, Zhongyuan Zuo, Liping Wang, Yarong Li, Jessica YJ Gu, Ulrich Tepass, Avital Adah Rodal, Hugo J Bellen, Joshua M Shulman
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications Ltd 2020-04-01
Seri Bilgileri:eLife
Konular:
VPS29
VPS35
Drosophila
endolysosomal trafficking
TBC1D5
Rab7
Online Erişim:https://elifesciences.org/articles/51977
Etiketler: Etiketle
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