The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia
Microglia are resident macrophages of the CNS that are essential for phagocytosis of apoptotic neurons and weak synapses during development. We show that RagA and Lamtor4, two components of the Rag-Ragulator complex, are essential regulators of lysosomes in microglia. In zebrafish lacking RagA funct...
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| Автори: | , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Elsevier
2016-01-01
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| Серія: | Cell Reports |
| Онлайн доступ: | http://www.sciencedirect.com/science/article/pii/S2211124715014965 |
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