Parametric and Nonparametric Population Pharmacokinetic Models to Assess Probability of Target Attainment of Imipenem Concentrations in Critically Ill Patients

Population pharmacokinetic modeling and simulation (M&S) are used to improve antibiotic dosing. Little is known about the differences in parametric and nonparametric M&S. Our objectives were to compare (1) the external validation of parametric and nonparametric models of imipenem in critically ill p...

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Bibliografski detalji

Glavni autori:	Femke de Velde, Brenda C. M. de Winter, Michael N. Neely, Jan Strojil, Walter M. Yamada, Stephan Harbarth, Angela Huttner, Teun van Gelder, Birgit C. P. Koch, Anouk E. Muller, on behalf of the COMBACTE-NET Consortium
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2021-12-01
Serija:	Pharmaceutics
Teme:	imipenem population pharmacokinetic modeling parametric nonparametric simulations
Online pristup:	https://www.mdpi.com/1999-4923/13/12/2170
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