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DNA binding, cleavage and anticancer activity of a Zn(II)-Cu(II) hetero-dinuclear carbohydrazone complex containing the secondary ligand 1,10-phenanthroline

A hetero di-nuclear complex [Zn(o-phen)LCu(OAc)] (1) (H3L = o-HOC6H4CH = NNH)2C = O, o-phen = 1,10-phenanthroline) exhibited intercalative DNA binding (Kb = 1.03 × 105 M−1) as revealed from UV–Vis spectral analysis as well as viscosity study and further supported by molecular docking study of 1 with...

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Principais autores: Sidhali U. Parsekar, Kumudini Paliwal, Paramita Haldar, Aditya P. Koley, Manjuri Kumar
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-12-01
Serier:Results in Chemistry
Fag:
Zn(II)-Cu(II) complex
Cell viability
Anticancer activity
Online adgang:http://www.sciencedirect.com/science/article/pii/S221171562300348X
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