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High-Efficacy α,β-Dehydromonacolin S Improves Hepatic Steatosis and Suppresses Gluconeogenesis Pathway in High-Fat Diet-Induced Obese Rats

Isolated α,β-dehydromonacolin S (<i>C5</i>) from soil-derived fungus <i>Aspergillus sclerotiorum</i> PSU-RSPG178 was recently shown to exhibit an inhibitory effect against 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) activity in vitro. In this study, we investigated the effects of <i>C5</i...

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Principais autores: Jutatip Kaewmalee, Atcharaporn Ontawong, Acharaporn Duangjai, Chittreeya Tansakul, Vatcharin Rukachaisirikul, Chatchai Muanprasat, Chutima Srimaroeng
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-04-01
Serier:Pharmaceuticals
Fag:
statin
α,β-dehydromonacolin S
lovastatin analog
3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
hepatic steatosis
type 2 diabetes mellitus
Online adgang:https://www.mdpi.com/1424-8247/14/4/375
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